基础研究:不同浓度灯盏细辛对SD大鼠蛛网膜下腔出血后血管痉挛的防治作用
2007-08-08
董凌琳，罗祖明，杨旭洪
【关键词】灯盏细辛；蛛网膜下腔出血；基底动脉
【摘要】目的：探讨不同浓度灯盏细辛对蛛网膜下腔出血（SAH）后脑血管痉挛（CVS）的防治作用。方法：72 只SD 大鼠随机分为A：假手术组；B：蛛网膜下腔出血模型组；C：低浓度灯盏细辛组；D：中浓度灯盏细辛组；E：高浓度灯盏细辛组；F：尼莫同组。经枕大池二次注血法建立SAH 后CVS 模型，用动态图像分析法监测基底动脉血管直径变化。结果：B 组基底动脉血管直径较A 组缩小（P < 0.001）；C、D、E、F 组血管直径与B组相比增大（P < 0.001），随着灯盏细辛浓度升高，C、D、E 组基底动脉的血管直径增大，其差异有显著性意义（P < 0.001）。结论：灯盏细辛对SD 大鼠SAH 后的CVS 的防治作用具有量效关系。
中图分类号：R743.35，R - 33 文献标识码：A
Therapeutic effects of different dosage Erigeron breviscapus on cerebral vascular spasm after subarachnoid hemorrhage of SD rats DONG Ling-lin*，LUO Zhu-ming，YANG Xuhong（（*Department of Neurology，Sichuan Provincial People67 8o7pital，9heng:u 610041，china）
【Abstract】Objective：To explore therapeutic effects of different dosage Erigeron breviscapus on cerebral vascularspasm（CVS）after experimental SAH.Motheds：Seventy-two SD rats were divided randomly into six groups，（a）controlgroup；（b）cerebral vasospasm group；（c-e）three different dosage Erigeron breviscapus groups；（f）Nimotop group. ExperementalSAH in SD rats was made by injecting blood for two times. Basilar artery diameter change was monitored by stereotypesmicroscopy.Results：Compared with that in cerebral vasospasms group，basilar artery diameters in three dosageErigeron breviscapus groups dilated（ P < 0.001），and dilated gradually with dosage of Eigeron breviscapus ascending.Conclusion：therapeutic effects of Erigeron breviscapus on cerebral vascular spasm
………
详情请到《相关下载》里下载全文